For roughly a year and a half, numerous Americans have quarantined themselves not just from work or school but from the other members of their households. Having more room in the residence and having particular floor plans would seem to help.
First, having more square feet would allow the residents to keep more distance and could provide the quarantined person more space to operate. Quarantining for a week or two could feel more burdensome if someone is restricted to a small room or portion of a residence. Space provides options for rearrangement.
Second, square footage might not be everything as the floor plan can matter. Large common spaces, a regular feature of many newer homes, would be off-limits. A more closed-off floor plan with separated rooms might work better. Even better could be a separate wing – imagine a bedroom and bathroom on one side of the house or on another level than the other bedrooms. For example, a split-level could be split between the quarantined and everyone else. Or, an in-law suite or numerous bedrooms with en suite bathrooms. In contrast, a ranch home with all the bedrooms near each other and a large living space might limit options.
Few people likely purchased their homes or rented particular places with a pandemic in mind. But, considering medical issues is not out of the question for many when looking for a place to live. Think of mobility concerns or aging in place. Or, if someone has a serious illness, where might a hospital bed fit or how would an alternative sleeping arrangement work out?
All I have is anecdotal evidence on this through observing the setups of people on social media. It appears most just block off a bedroom or office type of space in the home for the quarantined person. This works well if you have extra space or a room that is used occasionally. I suspect this is not so easy with less space or a layout that makes it difficult to isolate a single person.