Two economists at the Federal Reserve Bank of Philadelphia looked at the effects of building highways and found a number of negative effects for Chicago neighborhoods near the highways :

The literature criticizing urban renewal and highway construction in major cities after World War II has made a similar point: the construction of highways broke up established neighborhoods and encouraged urban residents to leave for the suburbs since they could easily access the city via highway.

At the same time, it sounds like this working paper suggests highways themselves are not necessarily the issue. The bigger problem may be that the highway is located on the surface and creating negative local effects including acting as barriers. Sometimes, this may be intentional such as when the Dan Ryan Expressway on Chicago’s South Side had the intended side effect of separating black and white neighborhoods. Other times, the highway could bisect what was a connected neighborhood and sever it. But, if the highway was underground, perhaps everyone could win: there would not be a 6-12 lane barrier, local neighborhoods would not see or hear the highway in the same way, and suburbanites could still access the city center. While it is hard to imagine, picture the Eisenhower headed into Chicago underground with parks, surface level streets, social and business activity, and a CTA line above it. Local residents could still have access to the highway without having to live right next to it.

This solution would likely not satisfy everyone. If the goal of countering highways is not just to protect neighborhoods but also to limit driving and promote mass transit, burying the highway is not enough. The eyesore may be gone but the larger problem still looms: Americans like driving and the associated lifestyle and too many cities are subservient to cars rather than to pedestrians and community life.